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1

Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study

Armando Santoro, Lorenza Rimassa, Ivan Borbath, Bruno Daniele, Stefania Salvagni, Jean Luc Van Laethem, Hans Van Vlierberghe, Jörg Trojan, Frank T Kolligs, Alan Weiss, Steven Miles, Antonio Gasbarrini

Journal:

The Lancet Oncology

Year:

2013

Language:

english

File:

PDF, 327 KB

english, 2013

2

Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib

Hammel, Pascal, Huguet, Florence, van Laethem, Jean-Luc, Goldstein, David, Glimelius, Bengt, Artru, Pascal, Borbath, Ivan, Bouché, Olivier, Shannon, Jenny, André, Thierry, Mineur, Laurent, Chibaudel,

Journal:

JAMA The Journal of the American Medical Association

Year:

2016

Language:

english

File:

PDF, 493 KB

english, 2016

3

Epidermal Growth Factor ReceptorandK-RASstatus in two cohorts of squamous cell carcinomas

Nancy Van Damme, Philippe Deron, Nadine Van Roy, Pieter Demetter, Alain Bols, Jo Van Dorpe, Filip Baert, Jean-Luc Van Laethem, Franki Speleman, Patrick Pauwels, Marc Peeters

Journal:

Year:

2010

Language:

english

File:

PDF, 2.32 MB

english, 2010

4

Current standards and new innovative approaches for treatment of pancreatic cancer

Conroy, Thierry, Bachet, Jean-Baptiste, Ayav, Ahmet, Huguet, Florence, Lambert, Aurélien, Caramella, Caroline, Maréchal, Raphaël, Van Laethem, Jean-Luc, Ducreux, Michel

Journal:

European Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 452 KB

english, 2016

5

Phylogenetic analysis of the Belgian HIV-1 epidemic reveals that local transmission is almost exclusively driven by men having sex with men despite presence of large African migrant communities

Verhofstede, Chris, Dauwe, Kenny, Fransen, Katrien, Van Laethem, Kristel, Van den Wijngaert, Sigi, Ruelle, Jean, Delforge, Marie-Luce, Vancutsem, Ellen, Vaira, Dolores, Stoffels, Karolien, Ribas, Serg

Journal:

Infection, Genetics and Evolution

Year:

2018

Language:

english

File:

PDF, 2.55 MB

english, 2018

6

Vagal nerve activity predicts overall survival in metastatic pancreatic cancer, mediated by inflammation

Couck, Marijke De, Maréchal, Raphaël, Moorthamers, Sofie, Laethem, Jean-Luc Van, Gidron, Yori

Journal:

Cancer Epidemiology

Year:

2016

Language:

english

File:

PDF, 421 KB

english, 2016

7

Cetuximab in combination with irinotecan/5-fluorouracil/folinic acid (FOLFIRI) in the initial treatment of metastatic colorectal cancer: a multicentre two-part phase I/II study

Jean-Luc Raoul, Jean-Luc Van Laethem, Marc Peeters, Catherine Brezault, Fares Husseini, Laurent Cals, Johannes Nippgen, Anja-Helena Loos, Philippe Rougier

Journal:

Year:

2009

Language:

english

File:

PDF, 890 KB

english, 2009

8

Association of Prognostic Value of Primary Tumor Location in Stage III Colon Cancer With RAS and BRAF Mutational Status

Taieb, Julien, Kourie, Hampig Raphael, Emile, Jean-François, Le Malicot, Karine, Balogoun, Ralyath, Tabernero, Josep, Mini, Enrico, Folprecht, Gunnar, Van Laethem, Jean-Luc, Mulot, Claire, Bouché, Oli

Journal:

Year:

2017

Language:

english

File:

PDF, 353 KB

english, 2017

9

Postoperative adjuvant gemcitabine and concurrent radiation after curative resection of pancreatic head carcinoma: a phase II study

Jean-Luc Van Laethem, Anne Demols, France Gay, Marie-Thérèse Closon, Maryvone Collette, Marc Polus, Ghislain Houbiers, Pauline Gastelblum, Michel Gelin, Paul Van Houtte, Jean Closset

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2003

Language:

english

File:

PDF, 84 KB

english, 2003

10

Transmitted drug resistance, selection of resistance mutations and moderate antiretroviral efficacy in HIV-2: Analysis of the HIV-2 Belgium and Luxembourg database

Jean Ruelle, François Roman, Anne-Thérèse Vandenbroucke, Christine Lambert, Katrien Fransen, Fedoua Echahidi, Denis Piérard, Chris Verhofstede, Kristel Van Laethem, Marie-Luce Delforge, Dolorès Vaira,

Journal:

BMC Infectious Diseases

Year:

2008

Language:

english

File:

PDF, 595 KB

english, 2008

11

Guidelines for time-to-event end-point definitions in trials for pancreatic cancer. Results of the DATECAN initiative (Definition for the Assessment of Time-to-event End-points in CANcer trials)

Bonnetain, Franck, Bonsing, Bert, Conroy, Thierry, Dousseau, Adelaide, Glimelius, Bengt, Haustermans, Karin, Lacaine, François, Van Laethem, Jean Luc, Aparicio, Thomas, Aust, Daniela, Bassi, Claudio,

Journal:

European Journal of Cancer

Year:

2014

Language:

english

File:

PDF, 631 KB

english, 2014

12

Treatment of Pancreatic Cancer: What Can We Really Predict Today?

Bachet, Jean-Baptiste, Marechal, Raphael, Van Laethem, Jean-Luc

Journal:

Year:

2011

Language:

english

File:

PDF, 236 KB

english, 2011

13

EVOLUTION OF RENAL FUNCTION DURING TREATMENT OF KIDNEY GRAFT REJECTION WITH OKT3 MONOCLONAL ANTIBODY

GOLDMAN, MICHEL, LAETHEM, JEAN-LUC VAN, ABRAMOWICZ, DANIEL, PAUW, LUC DE, KINNAERT, PAUL, VEREERSTRAETEN, PIERRE

Journal:

Transplantation Journal

Year:

1990

File:

PDF, 362 KB

1990

14

A phase II study of antibody-drug conjugate, TAK-264 (MLN0264) in previously treated patients with advanced or metastatic pancreatic adenocarcinoma expressing guanylyl cyclase C

Almhanna, Khaldoun, Wright, David, Mercade, Teresa Macarulla, Van Laethem, Jean-Luc, Gracian, Antonio Cubillo, Guillen-Ponce, Carmen, Faris, Jason, Lopez, Carolina Muriel, Hubner, Richard A., Bendell,

Journal:

Investigational New Drugs

Year:

2017

Language:

english

File:

PDF, 452 KB

english, 2017

15

CLINICAL EXPERIENCES WITH “THIRD GENERATION” CEPHALOSPORINS

Laethem, Yves Van, Clumeck, Nathan, Vanderauwera, Philippe, Jaspar, Nadine, Kutzler, Jean Paul

Journal:

Critical Care Medicine

Year:

1981

File:

PDF, 103 KB

1981

16

Prognostic nomogram and score to predict overall survival in locally advanced untreated pancreatic cancer (PROLAP)

Vernerey, Dewi, Huguet, Florence, Vienot, Angélique, Goldstein, David, Paget-Bailly, Sophie, Van Laethem, Jean-Luc, Glimelius, Bengt, Artru, Pascal, Moore, Malcolm J, André, Thierry, Mineur, Laurent,

Journal:

British Journal of Cancer

Year:

2016

Language:

english

File:

PDF, 319 KB

english, 2016

17

Decision tree for accurate infection timing in individuals newly diagnosed with HIV-1 infection

Verhofstede, Chris, Fransen, Katrien, Van Den Heuvel, Annelies, Van Laethem, Kristel, Ruelle, Jean, Vancutsem, Ellen, Stoffels, Karolien, Van den Wijngaert, Sigi, Delforge, Marie-Luce, Vaira, Dolores,

Journal:

BMC Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 1.45 MB

english, 2017

18

The Prognostic Significance of Metabolic Response Heterogeneity in Metastatic Colorectal Cancer

Hendlisz, Alain, Deleporte, Amelie, Delaunoit, Thierry, Maréchal, Raphaël, Peeters, Marc, Holbrechts, Stéphane, Van den Eynde, Marc, Houbiers, Ghislain, Filleul, Bertrand, Van Laethem, Jean-Luc, Ceyss

Journal:

Year:

2015

Language:

english

File:

PDF, 1.78 MB

english, 2015

19

The lack of selection criteria for surgery in patients with non-colorectal non-neuroendocrine liver metastases

Bohlok, Ali, Lucidi, Valerio, Bouazza, Fikri, Daher, Ali, Germanova, Desislava, Van Laethem, Jean Luc, Hendlisz, Alain, Donckier, Vincent

Journal:

World Journal of Surgical Oncology

Year:

2020

File:

PDF, 717 KB

2020

20

O-0006 Dose Escalation to Rash for Erlotinib Plus Gemcitabine in Patients with Metastatic Pancreatic Cancer: The Phase II RACHEL (BO21128) Study

Van Cutsem, Eric, Nowara, Elzbieta, Ciuleanu, Tudor, Aprile, Giuseppe, Moore, Malcolm, Federowicz, Irena, Van Laethem, Jean Luc, Hsu, Chiun, Ali, Sajid, Csutor, Zsuzsanna, Meng, Xianhua, Li, Chung-Pin

Journal:

Annals of Oncology

Year:

2012

File:

PDF, 130 KB

2012

21

Correlation Between the Response to Cetuximab Alone or in Combination With Irinotecan and the Activated/Phosphorylated Epidermal Growth Factor Receptor in Metastatic Colorectal Cancer

Nicola Personeni, Alain Hendlisz, Julien Gallez, Maria Gomez Galdon, Denis Larsimont, Jean-Luc Van Laethem, Nathalie Nagy, Martine Barette, Marianne Paesmans, Fatima Cardoso, Harry Bleiberg

Journal:

Seminars in Oncology

Year:

2005

Language:

english

File:

PDF, 96 KB

english, 2005

22

Cetuximab

Jean-Luc Van Laethem

Journal:

Year:

2004

Language:

english

File:

PDF, 52 KB

english, 2004

23

Addressing the challenges of pancreatic cancer: Future directions for improving outcomes

Hidalgo, Manuel, Cascinu, Stefano, Kleeff, Jörg, Labianca, Roberto, Löhr, J.-Matthias, Neoptolemos, John, Real, Francisco X., Van Laethem, Jean-Luc, Heinemann, Volker

Journal:

Year:

2015

Language:

english

File:

PDF, 1.02 MB

english, 2015

24

Distal pancreatectomy for pancreatic neoplasia: is splenectomy really necessary? A bicentric retrospective analysis of surgical specimens

Navez, Julie, Marique, Lancelot, Hubert, Catherine, Van Laethem, Jean-Luc, Komuta, Mina, Maris, Calliope, D'Haene, Nicky, Navez, Benoit, Closset, Jean

Journal:

Year:

2020

File:

PDF, 400 KB

2020

25

Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice

Hubert Louis, Jean-Luc Van Laethem, Wei Wu, Eric Quertinmont, Chantal Degraef, Kit Van den Berg, Anne Demols, Michel Goldman, Olivier Le Moine, Albert Geerts, Jacques Devière

Journal:

Year:

1998

Language:

english

File:

PDF, 1.35 MB

english, 1998

26

Prognostic Value of BRAF and KRAS Mutations in MSI and MSS Stage III Colon Cancer

Taieb, Julien, Le Malicot, Karine, Shi, Qian, Penault Lorca, Frédérique, Bouché, Olivier, Tabernero, Josep, Mini, Enrico, Goldberg, Richard M., Folprecht, Gunnar, Luc Van Laethem, Jean, Sargent, Danie

Journal:

JNCI Journal of the National Cancer Institute

Year:

2017

Language:

english

File:

PDF, 1.22 MB

english, 2017

27

Expression of transforming growth factor β receptors in normal human colon and sporadic adenocarcinomas

Rally Eskinazi, Anne Resibois, Michal Svoboda, Marie-Odile Peny, Michael Adler, Patrick Robberecht, Jean-Luc van Laethem

Journal:

Gastroenterology

Year:

1998

Language:

english

File:

PDF, 894 KB

english, 1998

28

Adjuvant chemotherapy in biliary tract cancer patients: A systematic review and meta-analysis of randomized controlled trials

Caparica, Rafael, Bruzzone, Marco, Hachem, Georges El, Ceppi, Marcello, Lambertini, Matteo, Glasberg, JoÃ£o, de Azambuja, Evandro, Van Laethem, Jean-Luc, Hendlisz, Alain

Journal:

Critical Reviews in Oncology/Hematology

Year:

2020

File:

PDF, 814 KB

2020

29

Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma

Raphaël Maréchal, John R. Mackey, Raymond Lai, Pieter Demetter, Marc Peeters, Marc Polus, Carol E. Cass, Isabelle Salmon, Jacques Devière, Jean-Luc Van Laethem

Journal:

Year:

2010

Language:

english

File:

PDF, 176 KB

english, 2010

30

Emerging drugs for the treatment of pancreatic cancer

Van Laethem, Jean-Luc, Marechal, Raphael

Journal:

Expert Opinion on Emerging Drugs

Year:

2007

Language:

english

File:

PDF, 186 KB

english, 2007

31

Localization of transforming growth factor β1 and its latent binding protein in human chronic pancreatitis

Jean-Luc Van Laethem, Jacques Deviere, Anne Resibois, Fabienne Rickaert, Pascale Vertongen, Haruo Ohtani, Michel Cremer, Kohei Miyazono, Patrick Robberecht

Journal:

Gastroenterology

Year:

1995

Language:

english

File:

PDF, 19.34 MB

english, 1995

32

Adjuvant therapy in gastric and cardia cancer: should we irradiate?

Van Laethem, Jean-Luc, Demols, Anne

Journal:

Current Opinion in Oncology

Year:

2006

Language:

english

File:

PDF, 114 KB

english, 2006

33

Salvage esophagectomy after failure of definitive radiochemotherapy for esophageal cancer

Farinella, Eleonora, Safar, Adonis, Nasser, Haydar A., Bouazza, Fikri, Liberale, Gabriele, Paesmans, Marianne, Marechal, Raphael, Van Laethem, Jean-Luc, Hendlisz, Alain, VanHoutte, Paul, El Nakadi, Is

Journal:

Journal of Surgical Oncology

Year:

2016

Language:

english

File:

PDF, 119 KB

english, 2016

34

Assessment of response to chemotherapy in pancreatic ductal adenocarcinoma: comparison between diffusion-weighted MR quantitative parameters and RECIST

Bali, Maria Antonietta, Pullini, Serena, Metens, Thierry, Absil, Julie, Chao, Shih-Li, Marechal, Raphael, Matos, Celso, Peerboccus, Bibi Mooneera, Van Laethem, Jean-Luc

Journal:

European Journal of Radiology

Year:

2018

Language:

english

File:

PDF, 993 KB

english, 2018

35

Systemic treatment of pancreatic cancer revisited

Ducreux, Michel, Seufferlein, Thomas, Van Laethem, Jean-Luc, Laurent-Puig, Pierre, Smolenschi, Cristina, Malka, David, Boige, Valérie, Hollebecque, Antoine, Conroy, Thierry

Journal:

Seminars in Oncology

Year:

2018

Language:

english

File:

PDF, 902 KB

english, 2018

36

Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials

Charette, Nicolas, Vandeputte, Caroline, Ameye, Lieveke, Bogaert, Camille Van, Krygier, Jonathan, Guiot, Thomas, Deleporte, Amélie, Delaunoit, Thierry, Geboes, Karen, Van Laethem, Jean-Luc, Peeters, M

Journal:

Year:

2019

Language:

english

File:

PDF, 854 KB

english, 2019

37

Association of post-operative CEA with survival and oxaliplatin benefit in patients with stage II colon cancer: a post hoc analysis of the MOSAIC trial

Auclin, Edouard, André, Thierry, Taieb, Julien, Banzi, Maria, Van Laethem, Jean-Luc, Tabernero, Josep, Hickish, Tamas, de Gramont, Aimery, Vernerey, Dewi

Journal:

British Journal of Cancer

Year:

2019

Language:

english

File:

PDF, 766 KB

english, 2019

38

Prognostic variables in low and high risk stage III colon cancers treated in two adjuvant chemotherapy trials

Sinicrope, Frank A., Chakrabarti, Sakti, Laurent-Puig, Pierre, Huebner, Luke, Smyrk, Thomas C., Tabernero, Josep, Mini, Enrico, Goldberg, Richard M., Zaanan, Aziz, Folprecht, Gunnar, Van Laethem, Jean

Journal:

European Journal of Cancer

Year:

2021

File:

PDF, 1.82 MB

2021

39

Squamous Cell Carcinoma of the Esophagus: Multimodal Therapy in Locally Advanced Disease

Issam El Nakadi, M.D., Jean-Luc Van Laethem, M.D., Jean-Jacques Houben, M.D., France Gay, M.D., Jean Closset, M.D., Paul Van Houtte, M.D., Serge Danhier, M.D., Jean-Michel Limbosch, M.D., Jean-Pierre

Journal:

World Journal of Surgery

Year:

2002

Language:

english

File:

PDF, 130 KB

english, 2002

40

Prognostic Effect of BRAF and KRAS Mutations in Patients With Stage III Colon Cancer Treated With Leucovorin, Fluorouracil, and Oxaliplatin With or Without Cetuximab

Taieb, Julien, Zaanan, Aziz, Le Malicot, Karine, Julié, Catherine, Blons, Hélène, Mineur, Laurent, Bennouna, Jaafar, Tabernero, Josep, Mini, Enrico, Folprecht, Gunnar, Van Laethem, Jean Luc, Lepage, C

Journal:

Year:

2016

Language:

english

File:

PDF, 476 KB

english, 2016

41

Phase II study of the antibody-drug conjugate TAK-264 (MLN0264) in patients with metastatic or recurrent adenocarcinoma of the stomach or gastroesophageal junction expressing guanylyl cyclase C

Almhanna, Khaldoun, Miron, Maria Luisa Limon, Wright, David, Gracian, Antonio Cubillo, Hubner, Richard A., Van Laethem, Jean-Luc, López, Carolina Muriel, Alsina, Maria, Muñoz, Frederico Longo, Bendell

Journal:

Investigational New Drugs

Year:

2017

File:

PDF, 5 KB

2017

42

New considerations for an overall approach to treat hepatocellular carcinoma in cirrhotic patients

Vincent Donckier, Jean Luc Van Laethem, Daniel Van Gansbeke, Brigitte Ickx, Pierre Lingier, Jean Closset, Issam El Nakadi, Pascale Feron, Nathalie Boon, Nadine Bourgeois, Michael Adler, Michel Gelin

Journal:

Journal of Surgical Oncology

Year:

2003

Language:

english

File:

PDF, 115 KB

english, 2003

43

Cefotaxime Therapy of Serious Infections with Multiresistant Gram-Negative Bacilli*

Clumeck, Nathan, Van Laethem, Yves, Vanhoof, Raymond, George, Claude, Rapin, Maurice, Butzler, Jean Paul

Journal:

Scandinavian Journal of Infectious Diseases

Year:

1982

Language:

english

File:

PDF, 496 KB

english, 1982

44

Multiple dideoxynucleoside analogue-resistant (MddNR) HIV-1 strains isolated from patients from different European countries

Schmit, Jean-Claude, Van Laethem, Kristel, Ruiz, Lidia, Hermans, Philippe, Sprecher, Suzanne, Sönnerborg, Anders, Leal, Manuel, Harrer, Thomas, Clotet, Bonaventura, Arendt, Vic, Lissen, Eduardo, Witvr

Journal:

Year:

1998

File:

PDF, 1.22 MB

1998

45

Screening and surveillance in hereditary gastrointestinal cancers: Recommendations from the European Society of Digestive Oncology (ESDO) expert discussion at the 20th European Society for Medical Oncology (ESMO)/World Congress on Gastrointestinal Cancer, Barcelona, June 2018

Vangala, Deepak B., Cauchin, Estelle, Balmaña, Judith, Wyrwicz, Lucian, van Cutsem, Eric, Güller, Ulrich, Castells, Antoni, Carneiro, Fatima, Hammel, Pascal, Ducreux, Michel, van Laethem, Jean-Luc, Ma

Journal:

European Journal of Cancer

Year:

2018

Language:

english

File:

PDF, 403 KB

english, 2018

46

Biliary tract cancers: From pathogenesis to endoscopic treatment

Anne Demols, Raphaël Maréchal, Jacques Devière, Jean-Luc Van Laethem

Journal:

Best Practice & Research Clinical Gastroenterology

Year:

2007

Language:

english

File:

PDF, 398 KB

english, 2007

47

The EORTC Gastrointestinal Tract Cancer Group: 50 years of research contributing to improved gastrointestinal cancer management

Gustavo Werutsky, Michel Ducreux, Manfred Lutz, Murielle Mauer, Eric Van Cutsem, Theo Ruers, Gunnar Folprecht, Markus Moehler, Daniela Aust, Jean-Luc Van Laethem, Florian Lordick, Bernard Nordlinger,

Journal:

European Journal of Cancer Supplements

Year:

2012

Language:

english

File:

PDF, 201 KB

english, 2012

48

3446 Using a 15.3 french biopsy forceps allows to obtain the anatomopathological diagnosis of upper gi lesions after failure using a standard, 7-fr, biopsy forceps.

Van Laethem, Jean-Luc, Debroux, Sebastien, Dumonceau, Jean-Marc, Peny, Marie-Odile, Remmelinck, Myriam, Salmon, Isabelle, Deviere, Jacques

Journal:

Gastrointestinal Endoscopy

Year:

2000

Language:

english

File:

PDF, 18 KB

english, 2000

49

Evaluation of Two Commercial Kits for the Detection of Genotypic Drug Resistance on a Panel of HIV Type 1 Subtypes A Through J

Fontaine, Elodie, Riva, Chiara, Peeters, Martine, Schmit, Jean-Claude, Delaporte, Eric, Van Laethem, Kristel, Van Vaerenbergh, Kristien, Snoeck, Joke, Van Wijngaerden, Erik, De Clercq, Erik, Van Ranst

Journal:

JAIDS Journal of Acquired Immune Deficiency Syndromes

Year:

2001

File:

PDF, 3.09 MB

2001

50

Different Expression of Transforming Growth Factor β1 in Pancreatic Ductal Adenocarcinoma and Cystic Neoplasms

Van Laethem, Jean-Luc, Resibois, Anne, Rickaert, Fabienne, Devière, Jacques, Gelin, Michel, Cremer, Michel, Robberecht, Patrick

Journal:

Year:

1997

Language:

english

File:

PDF, 2.45 MB

english, 1997

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